Professor Tim Cover

Timothy Cover is Professor of Medicine and Professor of Pathology, Microbiology and Immunology at Vanderbilt University School of Medicine. His research interests are directed toward bacteria-host interactions relevant for development of cancer, focusing in particular on the bacterium Helicobacter pylori and its role in the pathogenesis of stomach cancer. His laboratory has made important contributions to our understanding of genetic variation among H. pylori strains and strain-specific H. pylori constituents that are determinants of gastric cancer risk. These include a pore-forming toxin (VacA), the effector protein CagA (regarded as a bacterial oncoprotein), and a type IV secretion system that mediates entry of CagA into host cells.